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To collect every message that is sent to addresses that do not (or no longer) exist in your domain, you can create a catch-all address.
Due to its specificities, it is not possible to set up an automatic response. This could otherwise cause waves of spam. However, it is possible to use it for specific recipients via Sieve scripts by adding these recipient addresses to the vacation instructions:
addresses ["email@example.com", "firstname.lastname@example.org"]